Detalhe da pesquisa
1.
Syrian hamster convalescence from prototype SARS-CoV-2 confers measurable protection against the attenuated disease caused by the Omicron variant.
PLoS Pathog
; 19(4): e1011293, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-37014911
2.
Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.
BMC Biol
; 20(1): 182, 2022 08 19.
Artigo
Inglês
| MEDLINE | ID: mdl-35986286
3.
Sequential Delivery of Live Attenuated Influenza Vaccine and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Ferret Model Can Reduce SARS-CoV-2 Shedding and Does Not Result in Enhanced Lung Pathology.
J Infect Dis
; 225(3): 404-412, 2022 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34893851
4.
Dose-Dependent Response to Infection with Ebola Virus in the Ferret Model and Evidence of Viral Evolution in the Eye.
J Virol
; 95(24): e0083321, 2021 11 23.
Artigo
Inglês
| MEDLINE | ID: mdl-34586862
5.
Point-of-care diagnostic assay for the detection of Zika virus using the recombinase polymerase amplification method.
J Gen Virol
; 99(8): 1012-1026, 2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29897329
6.
Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors.
Bioorg Med Chem Lett
; 26(19): 4606-4612, 2016 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27578246
7.
A Chemical Probe for the ATAD2 Bromodomain.
Angew Chem Int Ed Engl
; 55(38): 11382-6, 2016 09 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27530368
8.
Lifeline caller response times and suicide prevention.
Aust N Z J Psychiatry
; 54(1): 10-11, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31096779
9.
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.
ACS Med Chem Lett
; 14(9): 1231-1236, 2023 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37736196
10.
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.
J Med Chem
; 65(3): 2262-2287, 2022 02 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34995458
11.
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg Med Chem Lett
; 21(20): 6188-94, 2011 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21903390
12.
Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit.
J Med Chem
; 64(15): 10806-10833, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34251219
13.
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.
J Med Chem
; 64(15): 10711-10741, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34260229
14.
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.
J Med Chem
; 64(15): 10742-10771, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34232650
15.
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(6): 3249-3281, 2021 03 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33662213
16.
One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model.
Vaccine
; 39(34): 4885-4894, 2021 08 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34253420
17.
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(15): 10772-10805, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34255512
18.
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.
J Med Chem
; 64(16): 12200-12227, 2021 08 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34387088
19.
Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model.
EBioMedicine
; 63: 103153, 2021 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-33279857
20.
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19.
Nat Commun
; 12(1): 1260, 2021 02 24.
Artigo
Inglês
| MEDLINE | ID: mdl-33627662